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KMID : 0391419930030020123
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Korean Journal of Lipidology
1993 Volume.3 No. 2 p.123 ~ p.132
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Periodic changes n levels of Lipid Peroxide and Vitamin E in Spontaneously hypertensive rats Fed High Cholesterol Diet
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류왕성
유언호/최영선/이희숙/조성희
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Abstract
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To investigate the effect of hypertension and high cholesterol diet on serum and liver levels of lipid peroxide and vitamin E, spontaneously hypertensive rats(SHRs) and Wistar rats were fed diets with or without 2% (wt/wt) cholesterol for 2, 4, 6
and 8
months. After 2 months of feeding, SHRs became apparently hypertensive and at 4th month, their systolic pressure was over 180 mmHg which was maintained until 8th month. Body weight gains almost ceased in SHRs after 4 months of feeding, Dietary
cholesterol had no effect on growth and blood pressure of either SHRs or Wistars.
Serum lipid peroxide levels measured as thiobarbituric acid reacting substances(TBARS) were higher in SHRs than in Wistar rats after 6 months. Liver levels appeared to be higher in SHR. Dietary cholesterol did not change TBARS levels in serum and
liver
of Wistar rats, but tended to increase the TBARS levels in SHRs. Compared with Wistar rats, serum vitamin E in SHRs were maintained at consistently low levels during 8 months, which were further reduced by dietary cholesterol after 4 months.
Liver
vitamin E contents were lower in SHRs than in Wistar rats at 6 th and 8 th month, but were not affected by dietary cholesterol. In liver triglyceride, content of C18:2n-6 fatty acid was higher in SHRS, while in liver phospholipid, contents of
C16:1
and
C16:1 fatty acids were increased by dietary cholesterol.
It is therefore concluded that the requirement for vitamin E is higher to maintain an appropriate status of vitamin E status and reduce the enhanced lipid peroxidation in hypertensive subjects.
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KEYWORD
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